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Murat H Digicaylioglu

from San Diego, CA
Age ~56

Murat Digicaylioglu Phones & Addresses

  • 5532 Renaissance Ave, San Diego, CA 92122 (858) 643-9363
  • 4024 Crystal Dawn Ln, San Diego, CA 92122 (858) 643-9363
  • 619 Hookberry Trl, San Antonio, TX 78256
  • Carlsbad, CA
  • Dorchester, MA

Publications

Us Patents

Neuroprotective Synergy Of Erythropoietin And Insulin-Like Growth Factor

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US Patent:
2004009, May 13, 2004
Filed:
Jun 11, 2003
Appl. No.:
10/460550
Inventors:
Murat Digicaylioglu - San Diego CA,
Stuart Lipton - Rancho Santa Fe CA,
International Classification:
A61K038/30
A61K038/18
US Classification:
514/012000
Abstract:
The present invention provides a method of providing acute neuroprotection by inducing the erythropoietin (EPO) signaling pathway in neuronal cells close to or subsequent to the time of excitatory insult; and inducing an insulin-like growth factor (IGF) signaling pathway in the neuronal cells close to or subsequent to the time of excitatory insult, thereby producing a synergistic acute neuroprotective effect in the neuronal cells. The invention also provides a method of preventing or reducing the severity of a neurologic condition in a subject by administering to the subject EPO or an active fragment or analog thereof at a dose of at most 2000 U/kg; and administering to the subject an IGF or an active fragment or analog thereof, thereby providing neuroprotection and preventing or reducing the severity of the neurologic condition. Such a method can be used to prevent or reduce the severity of, for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, amyotrophic lateral sclerosis, multiple sclerosis, a movement disorder, HIV-associated dementia, HIV-associated neuropathy, neuropathic pain, migraine, glaucoma, drug addiction, drug withdrawal, drug dependency, depression or anxiety.

Pharmaceutical Compositions For Treating Painful Neuropathy And Methods Of Treating Same

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US Patent:
2005000, Jan 6, 2005
Filed:
Mar 25, 2004
Appl. No.:
10/810362
Inventors:
Murat Digicaylioglu - San Diego CA,
Stuart Lipton - Rancho Santa Fe CA,
International Classification:
A61K038/18
A61K038/17
US Classification:
514012000
Abstract:
The present invention provides novel methods and compositions for the treatment and prevention of HIV-associated dementia (HAD), minor cognitive/motor disorder (MCMD), neuropathic pain associated with HAD, or neuropathic pain from other causes.

Neuroprotective Synergy Of Erythropoietin And Insulin-Like Growth Factors

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US Patent:
2009009, Apr 9, 2009
Filed:
Oct 15, 2008
Appl. No.:
12/252093
Inventors:
Murat Digicaylioglu - San Diego CA,
Stuart A. Lipton - Rancho Santa Fe CA,
Assignee:
Burnham Institute for Medical Research - La Jolla CA
International Classification:
A61K 38/30
C12N 5/02
A61K 38/22
A61P 25/28
A61P 25/16
A61P 25/22
A61P 25/24
A61P 25/36
A61P 25/14
A61P 25/06
US Classification:
514 12, 435375
Abstract:
The present invention provides a method of providing acute neuroprotection by inducing the erythropoietin (EPO) signaling pathway in neuronal cells close to or subsequent to the time of excitatory insult; and inducing an insulin-like growth factor (IGF) signaling pathway in the neuronal cells close to or subsequent to the time of excitatory insult, thereby producing a synergistic acute neuroprotective effect in the neuronal cells. The invention also provides a method of preventing or reducing the severity of a neurologic condition in a subject by administering to the subject EPO or an active fragment or analog thereof at a dose of at most 2000 U/kg; and administering to the subject an IGF or an active fragment or analog thereof, thereby providing neuroprotection and preventing or reducing the severity of the neurologic condition. Such a method can be used to prevent or reduce the severity of, for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, amyotrophic lateral sclerosis, multiple sclerosis, a movement disorder, HIV-associated dementia, HIV-associated neuropathy, neuropathic pain, migraine, glaucoma, drug addiction, drug withdrawal, drug dependency, depression or anxiety.
Murat H Digicaylioglu from San Diego, CA, age ~56 Get Report